What you'll need is four strobe lights all equipped with soft diffusers and receivers. Two barn doors, to shadow your subject from the knockout light. The barn doors need to be as tall and wide as your subject. A roll of white paper for the background and a capable camera.
Ignore the distances, and percentages in the diagram. Your studio setup will be different, this is intended to give you an idea of the setup. With a little experimentation you will never have to pick-up a path again. ; )
Oh snap, don't forget how to isolate using software just yet. Isolating with lights won't take advantage of the .PNG format. Depending on the subject, you may want to spend the time to remove the background with Photoshop, or the like, so you can sell the photo with that sweet checkered background.